isopenicillin N synthase | |||||||||
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Identifiers | |||||||||
EC no. | 1.21.3.1 | ||||||||
CAS no. | 78642-31-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Isopenicillin N synthase (IPNS) is a non-heme iron protein belonging to the 2-oxoglutarate (2OG)-dependent dioxygenases oxidoreductase family. This enzyme catalyzes the formation of isopenicillin N from δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (LLD-ACV).
This reaction is a key step in the biosynthesis of penicillin and cephalosporin antibiotics.[1]
The active sites of most isopenicillin N synthases contain an iron ion.[2]
This enzyme is also called isopenicillin N synthetase.